Roxicef S125/Roxicef S250/Roxicef Adverse Reactions

Roxicef S125/Roxicef S250: The most common are hypersensitivity reactions including skin rashes, urticarial, eosinophilia, fever, reactions resembling serum sickness and anaphylaxis.
There may be positive response to the Coombs' test although haemolytic anaemia rarely occurs. Neutropenia and thrombocytopenia have occasionally been reported. Agranulocytosis has been associated rarely with some cephalosporins. Bleeding complications related to hypoprothrombinaemia and/or platelet dysfunction have been occurred especially with cephalosporins and cephamycins having a methylthiotetrazole side-chain, including cefamandole, cefbuperazone, cefmenoximem, cefmenoxime, cefmetazole, cefonicid, cefoperazone, ceforanide, cefotetan, cefpiramide and latamoxef. The presence of a methyliadiazolethiol side-chain, as in cefazolin or an N-methylthiotriazine ring, as in ceftriaxone, might also be associated with such bleeding disorders.
Gastrointestinal disturbances, including diarrhea, nausea and vomiting have occurred in some patients receiving cefuroxime axetil. There have been rare reports of erythema multiforme. Stevens-Johnson syndrome, and toxic epidermal necrolysis. Mild to moderate hearing loss has been reported in some children given cefuroxime for the treatment of meningitis.
Roxicef: Pain at intramuscular injection site, thrombophlebitis after intravenous administration. Pseudomembranous colitis, leukopenia, thrombocytopenia, positive Coombs' test. Hypersensitivity reactions eg, rash, urticaria and anaphylaxis.